Betamethasone 17-Valerate (micronised) equivalent to Betamethasone 0.1% w/w.
Chlorocresol 0.1% w/w as preservative.
Pharmacology: Mechanism of Action: Betamethasone 17-valerate, a synthetic glucocorticoid, is thought to act by controlling the rate of synthesis of protein. It reacts with receptor proteins in the cytoplasm of sensitive cells to form a steroid-receptor complex which under goes a conformational change.
For the treatment of eczema, including atopic, infantile, discoid and stasis eczema; prurigo; psoriasis; neurodermatoses, including lichen simplex; lichen planus; seborrhoiec dermatitis; intertrigo; contact sensitivity reactions; discoid lupus erythematosus; generalised erythroderma; insect bites; otitis externa.
Apply small quantity to the affected skin 2 or 3 times daily until improvement occurs. It may then be possible to maintain improvement by applying once a day, or even less often. In the more resistant lesions such as the thickened plagues of psoriasis on elbows and knees, the effect of the preparation can be enhanced by occluding overnight the treatment area with polythene film; thereafter improvement can be maintained by regular application without occlusion.
Toxic effects are nearly always signs of overdosage and should be treated symptomatically, and dosages reduced or the drug slowly withdrawn. During prolong treatment, laboratory and metabolic studies should be made; measurement of the fluid intake and output, and daily weight record, may give early warning of fluid retention. Sodium intake may need to be reduced to less than 1g daily and potassium supplements may be necessary.
Rosacea, acne and peri-oral dermatitis. Skin lesions caused by infection with viruses (e.g. herpes simplex, chickenpox), fungi (e.g. candidiasis, tinea) or bacteria (e.g. impetigo).
Long-term continous topical therapy should be avoided where possible, particularly in infants and children. The face, more than other areas of the body, may exhibits atrophic changes after prolonged treatment. Application to the eyelids may cause glaucoma. Any spread of infection requires withdrawal of the product and systemic administration of antimicrobial agents. Avoid extensive use in pregnancy.
Avoid extensive use in pregnancy.
Prolonged and intensive treatment may cause local atropic changes in the skin such as striae, thinning, and dilatation of the superficial blood vessels, particularly when occlusive dressings are used or when skin folds are involved. Prolonged use of large amounts, or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercorticism, and is more likely to occur in infants and children or if occlusive dressings (or napkin) are used. In rare instances, treatment of psoriasis (or its withdrawal) is thought to have provoked the pustular form of the disease. Betamethasone is usually well tolerated, but if signs of hypersensitivity appear, therapy should stop immediately.
Keep container well closed. Store below 30°C.
Protect from light.
D07AC01 - betamethasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
Axcel Betamethasone cream 0.1% w/w
15 g x 1's
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